Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels.

ABSTRACT: Pentameric ligand-gated ion channels (pLGICs) are cell surface receptors of crucial importance for animal physiology^1-4. This diverse protein family mediates the ionotropic signals triggered by major neurotransmitters and includes γ-aminobutyric acid receptors (GABA_ARs) and acetylcholine receptors (nAChRs). Receptor function is fine-tuned by a myriad of endogenous and pharmacological modulators³. A functional pLGIC is built from five homologous, sometimes identical, subunits, each containing a β-scaffold extracellular domain (ECD), a four-helix transmembrane domain (TMD) and intracellular loops of variable length. Although considerable progress has been made in understanding pLGICs in structural and functional terms, the molecular mechanisms that enable the

SUBMITTER: Hooda Y 

PROVIDER: S-EPMC11565801 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature