GENCODE: massively expanding the lncRNA catalog through capture long-read RNA sequencing.

ABSTRACT: Accurate and complete gene annotations are indispensable for understanding how genome sequences encode biological functions. For twenty years, the GENCODE consortium has developed reference annotations for the human and mouse genomes, becoming a foundation for biomedical and genomics communities worldwide. Nevertheless, collections of important yet poorly-understood gene classes like long non-coding RNAs (lncRNAs) remain incomplete and scattered across multiple, uncoordinated catalogs, slowing down progress in the field. To address these issues, GENCODE has undertaken the most comprehensive lncRNAs annotation effort to date. This is founded on the manual annotation of full-length targeted long-read sequencing, on matched embryonic and adult tissues, of orthologous regions in human and mous

SUBMITTER: Kaur G 

PROVIDER: S-EPMC11565817 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature