Altered renal vascular patterning reduces ischemic kidney injury and limits vascular loss associated with aging.

ABSTRACT: The kidney vasculature has a complex arrangement, which runs in both series and parallel to perfuse the renal tissue and appropriately filter plasma. Recent studies have demonstrated that the development of this vascular pattern is dependent on netrin-1 secreted by renal stromal progenitors. Mice lacking netrin-1 develop an arterial tree with stochastic branching, particularly of the large interlobar vessels. The current study investigated whether abnormalities in renal vascular pattern altered kidney function or response to injury. To examine this, we analyzed kidney function at baseline as well as in response to recovery from a model of bilateral ischemic injury and measured vascular dynamics in aged mice. We found no differences in kidney function or morphology at baseline between mice

SUBMITTER: McLarnon SR 

PROVIDER: S-EPMC11565873 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature