Whole-Genome Sequencing of Invasive Neonatal Escherichia coli From Uppsala County, Sweden.

ABSTRACT:

Background

This study sought to investigate associations between virulence factors and phylogeny in all neonatal Escherichia coli bloodstream infections from patients admitted to the neonatal intensive care unit at Uppsala University Hospital between 2005 and 2020.

Methods

A total of 37 E. coli isolates from 32 neonates were whole-genome sequenced and analyzed for virulence factors related to extraintestinal E. coli; patient-related data were collected retrospectively from the medical records.

Results

E. coli isolates that belong to phylogroup B2 were associated with mortality (odds ratio [OR], 26; P < .001), extreme prematurity with delivery before gestational week 28 (OR, 9; P < .05), and shock (OR, 9; P < .05) compared with isolates of non-B2 group. Female neonates

SUBMITTER: Heydecke A 

PROVIDER: S-EPMC11565901 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature