Chlamydia trachomatis TmeA promotes pedestal formation through N-WASP and TOCA-1 interactions.

ABSTRACT: Chlamydia trachomatis (C.t.) is the causative agent of several human diseases, including the sexually transmitted infection chlamydia and eye infection trachoma. As an obligate intracellular bacterial pathogen, invasion is essential for establishing infection and subsequent pathogenesis. To facilitate invasion, C.t. secretes effector proteins through its type III secretion system (T3SS). These effectors facilitate bacterial entry by manipulating multiple pathways involved in host actin cytoskeletal regulation. Previous studies have demonstrated that the T3SS effector protein TmeA is crucial for C.t. invasion, as it recruits and activates N-WASP. This interaction leads to recruitment and activation of the Arp2/3 complex, promoting cytoskeletal rearrangements at t

SUBMITTER: McCullough A 

PROVIDER: S-EPMC11565925 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature