VCAN in the extracellular matrix drives glioma recurrence by enhancing cell proliferation and migration.

ABSTRACT:

Introduction

Gliomas are the most prevalent primary malignant intracranial tumors, characterized by high rates of therapy resistance, recurrence, and mortality. A major factor contributing to the poor prognosis of gliomas is their ability to diffusely infiltrate surrounding and even distant brain tissues, rendering complete total resection almost impossible and leading to frequent recurrences. The extracellular matrix (ECM) plays a key role in the tumor microenvironment and may significantly influence glioma progression, recurrence, and therapeutic response.

Methods

In this study, we first identified the ECM and the Versican (VCAN), a key ECM protein, as critical contributors to glioma recurrence through a comprehensive analysis of transcriptomic data comparing recurrent and

SUBMITTER: Wei R 

PROVIDER: S-EPMC11565936 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature