Reactive Oxygen Detoxification Contributes to <i>Mycobacterium abscessus</i> Antibiotic Survival.

ABSTRACT: When a population of bacteria are exposed to a bactericidal antibiotic most cells die rapidly. However, a sub-population of antibiotic-tolerant cells known as "persister cells" can survive for prolonged periods, and antibiotic tolerance can be strongly induced in a population by stresses such as nutrient deprivation. However, the pathways required to maintain viability in this setting, and how they are regulated are poorly understood. To identify genetic determinants of antibiotic tolerance in mycobacteria, we carried out transposon mutagenesis insertion sequencing (Tn-Seq) screens in Mycobacterium abscessus ( Mabs ) exposed to bactericidal translation-inhibiting antibiotics. This analysis identified genes essential for the survival of both spontaneous persister cells as well

SUBMITTER: Bates NA 

PROVIDER: S-EPMC11565942 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature