Streamlining Asymmetry Quantification in Fetal Mouse Imaging: A Semi-Automated Pipeline Supported by Expert Guidance.

ABSTRACT: Asymmetry is a key feature of numerous developmental disorders and in phenotypic screens is often used as a readout for environmental or genetic perturbations to normal development. A better understanding of the genetic basis of asymmetry and its relationship to disease susceptibility will help unravel the complex genetic and environmental factors and their interactions that increase risk in a range of developmental disorders. Large-scale imaging datasets offer opportunities to work with sample sizes needed to detect and quantify differences in morphology beyond severe deformities while also posing challenges to manual phenotyping protocols. In this work, we introduce a semi-automated open-source workflow to quantify abnormal asymmetry of craniofacial structures that integrates expert anat

SUBMITTER: Rolfe SM 

PROVIDER: S-EPMC11565955 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature