A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.

ABSTRACT: The cerebellum plays important roles in motor, cognitive, and emotional behaviors. Previous cerebellar coordinate-based meta-analyses (CBMAs) have complemented precision-mapping and parcellation approaches by finding generalizable cerebellar activations across the largest possible set of behaviors. However, cerebellar CBMAs face challenges due to inherent methodological limitations exacerbated by historical cerebellar neglect in neuroimaging. Here, we show overrepresentation of superior activations, rendering the null hypothesis of standard activation likelihood estimation (ALE) unsuitable. Our new method, cerebellum-specific ALE (C-SALE), finds behavioral convergence beyond baseline activation rates. It does this by testing experimental activations versus null models sampled from a data-d

SUBMITTER: Magielse N 

PROVIDER: S-EPMC11565958 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature