Consistent hierarchies of single-neuron timescales in mice, macaques and humans.

ABSTRACT: The intrinsic timescales of single neurons are thought to be hierarchically organized across the cortex. This conclusion, however, is primarily based on analyses of neural responses from macaques. Whether hierarchical variation in timescales is a general brain organizing principle across mammals remains unclear. Here we took a cross-species approach and estimated neuronal timescales of thousands of single neurons recorded across multiple areas in mice, monkeys, and humans using a task-agnostic method. We identify largely consistent hierarchies of timescales in frontal and limbic regions across species: hippocampus had the shortest timescale whereas anterior cingulate cortex had the longest. Within this scheme, variability across species was found, most notably in amygdala and orbitofrontal

SUBMITTER: Zeisler ZR 

PROVIDER: S-EPMC11565977 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature