Synchronous activation of striatal cholinergic interneurons induces local serotonin release.

ABSTRACT: Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors (nAChRs) on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.

SUBMITTER: Matityahu L 

PROVIDER: S-EPMC11566013 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature