The role of REM sleep in neural differentiation of memories in the hippocampus.

ABSTRACT: When faced with a familiar situation, we can use memory to make predictions about what will happen next. If such predictions turn out to be erroneous, the brain can adapt by differentiating the representations of the cues that generated the prediction from the mispredicted item itself, reducing the likelihood of future prediction errors. Prior work by Kim et al. (2017) found that violating a sequential association in a statistical learning paradigm triggered differentiation of the neural representations of the associated items in the hippocampus. Here, we used fMRI to test the preregistered hypothesis that this hippocampal differentiation occurs only when violations are followed by rapid eye movement (REM) sleep. In the morning, participants first learned that some items predict others (e.

SUBMITTER: McDevitt EA 

PROVIDER: S-EPMC11566016 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature