Pyramidal cell types and 5-HT_2A receptors are essential for psilocybin's lasting drug action.

ABSTRACT: Psilocybin is a serotonergic psychedelic with therapeutic potential for treating mental illnesses^1-4. At the cellular level, psychedelics induce structural neural plasticity^5,6, exemplified by the drug-evoked growth and remodeling of dendritic spines in cortical pyramidal cells^7-9. A key question is how these cellular modifications map onto cell type-specific circuits to produce psychedelics' behavioral actions¹⁰. Here, we use in vivo optical imaging, chemogenetic perturbation, and cell type-specific electrophysiology to investigate the impact of psilocybin on the two main types of pyramidal cells in the mouse medial frontal cortex. We find that a single dose of psilocybin increased the density of dendritic spines in both the subcortical-p

SUBMITTER: Shao LX 

PROVIDER: S-EPMC11566025 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature