A Normal Forced Vital Capacity Does Not Reliably or Equitably Exclude Restriction.

ABSTRACT:

Background

European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation recommend the use of a normal forced vital capacity (FVC) to exclude restriction. However, this recommendation is based upon a single study from 1999, which was limited to White patients, and used race-specific reference equations that are no longer recommended by ERS/ATS. We sought to reassess the support for this recommendation by calculating the negative predictive value (NPV) of a normal FVC in a diverse, multicenter cohort using race-neutral reference equations.

Methods

We interpreted PFTs performed between 2000 and 2023 in two academic medical systems and in a national electronic health record (EHR) database. We calculated the NPV

SUBMITTER: Moffett AT 

PROVIDER: S-EPMC11566032 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature