Six-Letter DNA Nanotechnology: Incorporation of <b>Z</b>-<b>P</b> Base Pairs into Self-Assembling 3D Crystals.

ABSTRACT: Artificially expanded genetic information systems (AEGIS) were developed to expand the diversity and functionality of biological systems. Recent experiments have shown that these expanded DNA molecular systems are robust platforms for information storage and retrieval as well as useful for basic biotechnologies. In tandem, nucleic acid nanotechnology has seen the use of information-based "semantomorphic" encoding to drive the self-assembly of a vast array of supramolecular devices. To establish the effectiveness of AEGIS toward nanotechnological applications, we investigated the ability of a six-letter alphabet composed of A:T, G:C and synthetic Z:P (Z, 6-amino-3-(1'-β-d-2'-deoxy ribofuranosyl)-5-nitro-(1H)-pyridin-2-one; P, 2-amino-8-(1'-β-d-2'-deoxyribo

SUBMITTER: Vecchioni S 

PROVIDER: S-EPMC11566107 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature