Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry.

ABSTRACT:

Purpose

Previous observational studies about the link between dietary factors and diabetic microvascular complications (DMCs) is controversial. Thus, we systemically assessed the potential causal relationship between diet and DMCs risk using Mendelian randomization (MR) methods.

Methods

We used genome-wide association studies (GWAS) statistics to estimate the causal effects of 17 dietary patterns on three common DMCs in European. Summary statistics on dietary intakes were obtained from the UK biobank, and data on DMCs [diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic neuropathy (DNP)] were obtained from the FinnGen Consortium. A two-sample MR (TSMR) was conducted to explore the causal relationships of dietary habits with DMCs. In addition, multivariable MR

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11566142 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature