Variations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits.

ABSTRACT:

Background

Immune dysregulation has been identified as a contributing factor in the pathophysiology of schizophrenia. This study aimed to investigate variations in specific immune regulators and their correlation with psychopathology and cognitive functions in male patients with chronic schizophrenia.

Methods

Employing a cross-sectional design, this study included 72 male patients with chronic schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status were utilized to assess psychopathology and cognitive functions, respectively.

Results

Serum levels of interleukin (IL)-4, IL-10, IL-12p40, IL-13, and monocyte chemoattractant protein-1 (MCP-1) were measured. There were significantly increase

SUBMITTER: Guo T 

PROVIDER: S-EPMC11566147 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature