Analysis of immune status and prognostic model incorporating lactic acid metabolism-associated genes.

ABSTRACT:

Background

Cancer development is intricately linked with metabolic dysregulation, including lactic acid metabolism, which plays a pivotal role in tumor progression and immune evasion. However, its specific implications in gastric adenocarcinoma (STAD) remain unclear. This study introduces a novel methodology to evaluate lactic acid metabolism comprehensively in STAD, aiming to elucidate its prognostic significance and impact on immunotherapy efficacy. Targeted therapies directed at key lactic acid metabolism genes (LMGs) identified within the tumor microenvironment (TME) hold promise for personalized treatment strategies.

Methods

Lactic acid metabolism patterns were assessed in 415 STAD patients using a panel of 21 LMGs. Cox regression and Lasso regression analyses were empl

SUBMITTER: Bao T 

PROVIDER: S-EPMC11566181 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature