Comparison of cell type and disease subset chromatin modifications in SLE.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations. There is little understanding of why some organs are specifically impacted in patients and the mechanisms of disease persistence remain unclear. While much work has been done characterizing the DNA methylation status in SLE, there is less information on histone modifications, a more dynamic epigenetic feature. This study identifies two histone marks of activation and the binding of p300 genome-wide in three cell types and three clinical subsets to better understand cell-specific effects and differences across clinical subsets.

Results

We examined 20 patients with SLE and 8 controls and found that individual chromatin marks varied considerably across T cells, B cells, and monoc

SUBMITTER: Beigel K 

PROVIDER: S-EPMC11566291 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature