Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma.

ABSTRACT:

Background

Ovarian clear cell carcinoma (OCCC) has a disproportionately high incidence among women in East Asia. Patients diagnosed with OCCC tend to experience worse clinical outcomes than those with high-grade serous carcinoma (HGSC) at advanced stages. The unfavorable prognosis of OCCC can be partly attributed to its frequent resistance to conventional chemotherapy. Within a precision medicine framework, we sought to provide a comprehensive molecular characterization of OCCC using whole-exome sequencing to uncover potential molecular targets that may inform novel therapeutic strategies.

Methods

We performed whole-exome sequencing analysis on tumor-normal paired samples from 102 OCCC patients. This comprehensive genomic characterization of a substantial cohort of OCCC spec

SUBMITTER: Chao A 

PROVIDER: S-EPMC11566382 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature