Exploring genetic associations between immune cells and hypertensive disorder of pregnancy using Mendelian randomization.

ABSTRACT:

Background

Observational epidemiological studies suggested that immunological dysregulation and inflammation play a significant role in the placental and renal dysfunction that leads to maternal hypertension. The immunophenotypes' possible causalities with hypertensive disease of pregnancy remain ambiguous. We performed two-sample Mendelian randomization (MR) analyses to comprehensively investigate the causal effect of immunophenotypes on hypertensive disorder of pregnancy (HDP).

Methods

The large-scale genome-wide association studies (GWASs) data on immunological traits was taken from public catalog for 731 immunophenotypes. The summarized GWAS data in 4 types of HDP were retrieved from FinnGen database, including 811,605 Finnish individuals. The primary analysis was the in

SUBMITTER: Liu J 

PROVIDER: S-EPMC11566496 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature