Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism.

ABSTRACT: The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life. Neuroinflammation, characterized by activation of microglia(MG) and release of cytokines, is closely associated with the onset of these neurodegenerative diseases. The activated status of MG is modulated by specifically programmed metabolic changes under various conditions. Succinylation, a novel post-translational modification(PTM) mainly involved in regulating mitochondrial energy metabolism pathways, remains unknown in its role in MG activation and aging. In the present study, we found that succinylation levels were significantly increased both during aging and upon lipopolysaccharide-induced(LPS-induced) MG activation

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11566524 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature