Causal associations of Sjogren's syndrome with cardiovascular disease: A two-sample Mendelian randomization study.

ABSTRACT:

Study objectives

Observational and cohort studies have associated Sjögren's syndrome (SS) with various types of cardiovascular disease (CVD), yet causal relationships have not been established. We employed Mendelian randomization (MR) to investigate potential causal links between SS and CVD in the general population.

Methods

We conducted a two-sample MR analysis using data from four distinct sources for 11 genome-wide significant single nucleotide polymorphisms (SNPs) associated with SS and data for 13 types of CVD sourced from FinnGen, IEU OpenGWAS, and GWAS catalog. The inverse variance weighted method was selected as the primary analytical approach, complemented by various sensitivity analyses.

Results

MR analyses provide evidence of a significantly increased risk

SUBMITTER: Su C 

PROVIDER: S-EPMC11566712 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature