Predicting the prognosis of Wilms tumor by peripheral blood cells: a real-world study of more than 30 years.

ABSTRACT:

Background

Despite established excellent treatment strategies for Wilms tumor (WT), effective prognostic evaluation methods were lacking. This study aims to examine prognostic factors for WT through real-world peripheral blood cell profiling.

Methods

Basic data and pre-treatment laboratory indices from WT and non-WT children underwent Wilcoxon test analysis. Chi-square tests assessed the correlation between blood cells and the overall survival (OS) and event-free survival (EFS) of WT. Further the Log-rank test and multivariate Cox were used to identify independent prognostic factors for OS. Traditional accepted factors were included in multi-Cox and the nomogram was constructed to further validate the outcome.

Results

Blood cells significantly differed between WT and

SUBMITTER: Jie L 

PROVIDER: S-EPMC11566747 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature