Mapping grey matter and cortical thickness alterations associated with subjective cognitive decline and mild cognitive impairment among rural-dwelling older adults in China: A population-based study.

ABSTRACT:

Background

The structural brain alterations for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are poorly defined. We sought to characterize grey matter volume (GMV) and cortical thickness associated with SCD and MCI among rural-dwelling older adults in China.

Methods

This population-based cross-sectional study included 1072 dementia-free participants from the brain MRI sub-study of MIND-China (2018-2020). We defined MCI following the Petersen's criteria, and SCD as the self-rated Ascertain Dementia 8-item Questionnaire score ≥ 2. Data were analyzed using voxel-based morphometry (VBM), surface-based morphometry analysis (SBM), and logistic regression models.

Results

SCD was defined in 243 persons and MCI in 246 individuals. The VBM analysis sho

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11566878 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature