Unraveling the DNA methylation landscape in dog blood across breeds.

ABSTRACT:

Background

DNA methylation is a covalent bond modification that is observed mainly at cytosine bases in the context of CG pairs. DNA methylation patterns reflect the status of individual tissues, such as cell composition, age, and the local environment, in mammals. Genetic factors also impact DNA methylation, and the genetic diversity among various dog breeds provides a valuable platform for exploring this topic. Compared to those in the human genome, studies on the profiling of methylation in the dog genome have been less comprehensive.

Results

Our study provides extensive profiling of DNA methylation in the whole blood of three dog breeds using whole-genome bisulfite sequencing. The difference in DNA methylation between breeds was moderate after removing CpGs overlapping w

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC11566899 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature