Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1.

ABSTRACT:

Background

Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there is a lack of effective drug treatment. As the major cells of sepsis-induced ALI, macrophages polarize toward the proinflammatory M1 phenotype and secrete multiple inflammatory cytokines to accelerate the disease process through nuclear factor kappa-B (NF-κB) and NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling pathways. Taraxerone, the main component of the Chinese medicinal Sedum, possesses numerous biological activities. However, uncertainty remains regarding the potential of taraxerone to protect against sepsis-induced ALI. This study aimed to investigate the effects and mechanisms of taraxerone against ALI.

Methods

An animal model for ALI was established by

SUBMITTER: Deng L 

PROVIDER: S-EPMC11566926 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature