Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study.

ABSTRACT: Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment-wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment interactions (G×E) on regional gray matter volumes were identified, with enriched biological functions related to metabolic process, inflammatory process, and synaptic plasticity. Additionally, genetic overlapping results with behavioral and disease-related phenotypes indicated shared biological mechanism between maternal education modified neurodevelopment and related behavioral traits. F

SUBMITTER: Shi R 

PROVIDER: S-EPMC11567010 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature