Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.

ABSTRACT: Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study. Altogether 6523 genetically predisposed children were enrolled to long-term follow-up with prospective sampling and data collection at six research centers in the USA, Germany, Sweden a

SUBMITTER: Euren A 

PROVIDER: S-EPMC11567144 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature