NAD⁺ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation.

ABSTRACT: The ovary experiences an age-dependent decline starting during the fourth decade of life. Ovarian aging is the predominant factor driving female reproductive aging. Modern trend to postpone childbearing age contributes to reduced fertility and natality worldwide. Recently, the beneficial role of NAD⁺ precursors on the maintenance of oocyte competence and female fertility affected by aging has emerged. Nevertheless, age-related changes in NAD⁺ regulatory network have not been investigated so far. In this context, our goal was to investigate changes induced by the aging process in the expression level of genes participating in NAD⁺ biosynthetic and NAD⁺ consuming pathways and in the cellular bioenergetics in the mouse oocyte. From Ingenuity Pathway

SUBMITTER: Di Emidio G 

PROVIDER: S-EPMC11567263 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature