The mouse gingiva and HIF-1α, a key gene of hypoxic environment, as tools for post-mortem time estimation.

ABSTRACT: The post-mortem interval (PMI) is the time elapsed between the death of an individual and its forensic examination. It is a crucial information for judicial authorities, but current techniques still cannot establish a precise time interval. Novel approaches are therefore required. Recently, gingival tissue has emerged as interesting for forensic analysis thanks to the protection offered by lips to this tissue, limiting the influence of environmental factors. It is also easily accessible, and its sampling is minimally invasive even in the presence of rigor mortis. Moreover, the expression of HIF-1α, a master mediator of the hypoxic environment, has been described in gingival samples at different post-mortem (PM) times. We have hypothesized that the time-dependent post-mortem expression of H

SUBMITTER: Mascarell S 

PROVIDER: S-EPMC11567532 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature