Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal-cortical connectivity.

ABSTRACT: Systems consolidation theories propose two mechanisms that enable the behavioral integration of related memories: coordinated reactivation between hippocampus and cortex, and the emergence of cortical traces that reflect overlap across memories. However, there is limited empirical evidence that links these mechanisms to the emergence of behavioral integration over time. In two experiments, participants implicitly encoded sequences of objects with overlapping structure. Assessment of behavioral integration showed that response times during a recognition task reflected behavioral priming between objects that never occurred together in time but belonged to overlapping sequences. This priming was consolidation-dependent and only emerged for sequences learned 24 hr prior to the test. Critically

SUBMITTER: Tompary A 

PROVIDER: S-EPMC11567667 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature