Association between mitochondrial DNA copy number and neurodevelopmental outcomes among black and white preterm infants up to two years of age.

ABSTRACT:

Objectives

Mitochondrial DNA copy number (mtDNAcn) is associated with mitochondrial function, with abnormal copy numbers having been linked to various disease states. Our study aims to understand the association between infant mtDNAcn and infant neurodevelopment, as well as the association with racial disparities.

Methods

A longitudinal study was conducted with 55 preterm infants from whom a single blood sample was collected during their Neonatal intensive care unit (NICU) stay and used to analyze mtDNAcn. In addition, the NICU Network Neurobehavioral Scale at 36-38 postmenstrual age (PMA) and the Bayley Scale of Infant and Toddler Development (Bayley) Edition III at 1 and 2 years of corrected age were both conducted. Linear regression models were performed to investigate th

SUBMITTER: Zhao T 

PROVIDER: S-EPMC11567671 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature