Dynamics of Ischemia/Reperfusion Injury Markers During Normothermic Liver Machine Perfusion.

ABSTRACT:

Background

A comprehensive mechanistic assessment of normothermic machine perfusion (NMP) is an essential step toward identifying biomarkers to assess liver viability. Although some studies have evaluated the effect of NMP on inflammation markers, there are other key pathological mechanisms involved in ischemia/reperfusion injury (IRI) that have not yet been evaluated.

Methods

Eight human donor livers preserved by NMP were included to analyze IRI during preservation. Concentrations of several biomarkers involved in different biological processes of IRI were measured in the perfusate.

Results

Perfusate levels of intercellular adhesion molecule 1, P-selectin, vascular cell adhesion molecule 1, metalloproteinase with thrombospondin motif type 1, member 13, phospholipase

SUBMITTER: Caballero-Marcos A 

PROVIDER: S-EPMC11567704 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature