Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort.

ABSTRACT:

Introduction

Prenatal phthalate exposure may influence lung development and lead to wheezing and asthma in childhood, and these associations may vary by sex. Despite ubiquity of exposure, there is limited epidemiologic data on these associations in Latin America.

Methods

We assessed 593 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors birth cohort in Mexico City. We quantified 15 phthalate metabolites in 2nd and 3rd trimester maternal urine. Report of ever wheeze, wheeze in the past 12 months (current wheeze) and ever asthma were obtained using a validated survey when children were 4 and 6 years of age. We examined individual associations with modified Poisson models. Mixture effects were assessed using Bayesian We

SUBMITTER: Alcala CS 

PROVIDER: S-EPMC11567787 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature