Multi-Functional Biomaterial for the Treatment and Prevention of Central Line-Associated Bloodstream Infections.

ABSTRACT: Central venous catheters are among the most used medical devices in hospitals today. Despite advances in modern medicine, catheter infections remain prevalent, causing significant morbidity and mortality worldwide. Here, SteriGel is reported, which is a multifunctional hydrogel engineered to prevent and treat central line-associated bloodstream infections (CLABSI). The mechanical properties of SteriGel are optimized to ensure appropriate gelation kinetics, bio-adhesiveness, stretchability, and recoverability to promote durability upon application and to provide persistent protection against infection. In vitro assays demonstrated that SteriGel exhibits long-term antimicrobial efficacy and has bactericidal effects against highly resistant patient-derived pathogens known to be frequently ass

SUBMITTER: Kim J 

PROVIDER: S-EPMC11567798 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature