Salience network segregation mediates the effect of tau pathology on mild behavioral impairment.

ABSTRACT:

Introduction

A recently developed mild behavioral impairment (MBI) diagnostic framework standardizes the early characterization of neuropsychiatric symptoms in older adults. However, the joint contributions of Alzheimer's disease (AD) pathology and brain function to MBI remain unclear.

Methods

We test a novel model assessing direct relationships between AD biomarker status and MBI symptoms, as well as mediated effects through segregation of the salience and default-mode networks, using data from 128 participants with diagnosis of amnestic mild cognitive impairment or mild dementia-AD type.

Results

We identified a mediated effect of tau positivity on MBI through functional segregation of the salience network from the other high-level, association networks. There were n

SUBMITTER: Iordan AD 

PROVIDER: S-EPMC11567810 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature