Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab.

ABSTRACT:

Introduction

Anti-amyloid antibody therapies such as lecanemab are increasingly being used to treat Alzheimer's disease (AD). These therapies are associated with a high rate of amyloid-related imaging abnormalities (ARIA).

Methods

We review the case history of a patient who developed ARIA associated with lecanemab treatment.

Results

In addition to microhemorrhages and cerebral edema that are recognized features of ARIA, the patient developed several ischemic strokes. The patient also experienced frequent electrographic seizures without overt clinical seizures. The patient demonstrated clinical and radiographic improvement after steroid treatment.

Discussion

Our case suggests that ischemic strokes may be a feature of ARIA and highlights the importance of having

SUBMITTER: Gibson AW 

PROVIDER: S-EPMC11567816 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature