The inverse association between cancer history and incident cognitive impairment: Addressing attrition bias.

ABSTRACT:

Introduction

Cancer is inversely associated with cognitive impairment. Whether this is due to statistical handling of attrition (death and censoring) is unknown.

Methods

We quantified associations between cancer history and incident cognitive impairment among Health, Aging, and Body Composition Study participants without baseline cognitive impairment or stroke (n = 2604) using multiple competing-risks models and their corresponding estimands: cause-specific, subdistribution, and marginal hazards, plus composite-outcome (cognitive impairment or all-cause mortality) hazards. All-cause mortality was also modeled.

Results

After covariate adjustment (demographics, apolipoprotein E ε4, lifestyle, health conditions), cause-specific and marginal hazard ratios (HRs) were simil

SUBMITTER: Shardell M 

PROVIDER: S-EPMC11567823 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature