APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve.

ABSTRACT:

Introduction

This study examines the role of lifestyle factors in cognitive reserve among older adults, focusing on the moderating effect of apolipoprotein E (APOE) ε4 status.

Methods

Data from 157 participants aged 45 and older from the Healthy Brain Initiative (HBI) were analyzed. Cognitive reserve was estimated using residual scores from Cognivue Clarity tests after accounting for brain atrophy and white matter hyperintensities (WMHs). Lifestyle factors included education, occupational attainment, physical activity, social engagement, diet, and mindfulness. Structural equation models were conducted to assess interactions.

Results

Significant interactions were found between APOE ε4 status and mindfulness and social engagement on cognitive reserve, indicating stronge

SUBMITTER: O'Shea DM 

PROVIDER: S-EPMC11567825 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature