Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.

ABSTRACT:

Introduction

MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis.

Methods

We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers.

Results

We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enr

SUBMITTER: Liu S 

PROVIDER: S-EPMC11567826 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature