Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease.

ABSTRACT:

Introduction

This study investigated the changes in functional capacity with disease progression in a well-characterised cohort of patients diagnosed with frontotemporal dementia (FTD) and Alzheimer's disease (AD) presentations.

Methods

We recruited 126 behavioural variant FTD (bvFTD), 40 progressive nonfluent aphasia (PNFA), 64 semantic dementia (SD), 45 logopenic progressive aphasia (LPA), and 115 AD patients. Functional capacity was measured annually over ∼7 years using the Disability Assessment for Dementia.

Results

Linear mixed effects models revealed the bvFTD group demonstrated disproportionate functional impairment at baseline and over the study period. Functional capacity among the other syndromes showed a more uniform pattern of decline, with less severe fun

SUBMITTER: Foxe D 

PROVIDER: S-EPMC11567831 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature