Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.

ABSTRACT:

Introduction

Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study.

Methods

Dementia and stroke-free participants underwent OLINK Proteomics profiling and MRI measurements within 5 years. Pairwise cross-sectional analysis assessed 68 biomarkers with 13 brain MRI volumes, adjusting for covariates and familial correlations.

Results

Elevated CDCP1, IL6, OPG, and 4E.BP1 were related to smaller total cerebral brain volume (TCBV), whereas higher HGF, IL8, and

SUBMITTER: Chen J 

PROVIDER: S-EPMC11567832 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature