Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease.

ABSTRACT:

Introduction

Microglial responses are an integral part of Alzheimer's disease (AD) pathology and are associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects of Aβ and microglial responses on global cognitive impairment.

Methods

In this longitudinal study, 28 patients with mild cognitive impairment and 11 healthy controls underwent ¹¹C-PK11195 and ¹¹C-Pittsburgh compound B positron emission tomography (PET), structural magnetic resonance imaging scans, and global cognitive ratings at baseline and 2-year follow-up. Correlations between PET uptake and global cognition were assessed. Additionally, the mediation effect of the microglial response on the association between Aβ load and global cognition was assessed.

Results

SUBMITTER: Madsen LS 

PROVIDER: S-EPMC11567839 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature