Circulating apoE4 protein levels from dried blood spots predict cognitive function in a large population-based survey setting.

ABSTRACT:

Introduction

The apolipoprotein E (APOE) ε4 allele carries risk for cognitive impairment, but whether the level of circulating apoE4 protein in carriers affects cognition is unclear, as is how health and lifestyle impact circulating apoE4 levels.

Methods

We assayed apoE4 protein levels in dried blood spots of 12,532 adults aged 50+. Regression analyses tested the likelihood of cognitive impairment between groups and within those with detected apoE4 protein. Predictors of circulating apoE4 were assessed.

Results

We detected protein binding that indicates the presence of an APOE ε4 allele in 28.4% of this group. This group was more likely to have cognitive impairment, and this risk increases with age. However, higher apoE4 levels were associated with less likelihood of

SUBMITTER: Deza-Lougovski YI 

PROVIDER: S-EPMC11567846 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature