Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy.

ABSTRACT:

Introduction

Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited.

Methods

We included Dutch-type hereditary CAA (D-CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age-matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI-cSVD burden and cognition.

Results

D-CAA ICH- mutation carriers exhibited poorer global cognition and executive func

SUBMITTER: van Dort R 

PROVIDER: S-EPMC11567850 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature