Self- and study partner-reported cognitive decline in older adults without dementia: The role of α-synuclein and amyloid biomarkers in the Alzheimer's Disease Neuroimaging Initiative.

ABSTRACT:

Introduction

Subjective cognitive decline (SCD) may be an early marker of Alzheimer's disease (AD) pathology. Until recently, it was impossible to measure biomarkers specific for α-synuclein pathology; therefore, its association with subjective reports of cognitive decline is unknown.

Methods

Alzheimer's Disease Neuroimaging Initiative participants without dementia (n = 918) were classified as positive or negative for amyloid beta (Aβ+ or Aβ-) and α-synuclein (α-syn+ or α-syn-) biomarkers. Self- and study partner-reported cognitive decline was measured with the Everyday Cognition (ECog) questionnaire.

Results

Per self-report, Aβ+/α-syn+ had the greatest cognitive decline. Aβ-/α-syn+ did not differ from Aβ-/α-syn- across ECog scores. Study partner-reported results had

SUBMITTER: Thomas KR 

PROVIDER: S-EPMC11567851 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature