Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) initiates years prior to symptoms, underscoring the importance of early detection. While amyloid accumulation starts early, individuals with substantial amyloid burden may remain cognitively normal, implying that amyloid alone is not sufficient for early risk assessment.

Methods

Given the genetic susceptibility of AD, a multi-factorial pseudotime approach was proposed to integrate amyloid imaging and genotype data for estimating a risk score. Validation involved association with cognitive decline and survival analysis across risk-stratified groups, focusing on patients with mild cognitive impairment (MCI).

Results

Our risk score outperformed amyloid composite standardized uptake value ratio in correlation with cognitive scores. MC

SUBMITTER: He B 

PROVIDER: S-EPMC11567859 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature