Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations.

Methods

Participants were 308 ADAD mutation carriers aged 39.7 ± 10.8 years from the Dominantly Inherited Alzheimer's Network. Weekly exercise volume was measured via questionnaire and associations with brain volume (magnetic resonance imaging), cerebrospinal fluid biomarkers, and brain amyloid beta (Aβ) measured by positron emission tomography were investigated.

Results

Greater volume of weekly exercise at baseline was associated with slower accumulation of brain Aβ at preclinical disease stages β = -0.16 [-0.23 to -0.08], and a slower decline in multiple brain regions includi

SUBMITTER: Sewell KR 

PROVIDER: S-EPMC11567864 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature