A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.

ABSTRACT:

Introduction

In the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies.

Methods

As part of the Rush Memory and Aging Project (n = 440), we measured accelerometer-based actigraphy, cognitive performance, and after brain autopsy, selected reaction monitoring mass spectrometry. Multilevel network analysis was used to examine the relationships among the molecular machinery of vesicular neurotransmission, Alzheimer's disease (AD) neuropathology, cognition, and late-life physical activity.

Results

Synaptic peptides involved in neuronal secretory function were the most influential contributors to the multilayer network, reflecting

SUBMITTER: Jones AA 

PROVIDER: S-EPMC11567865 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature